If any of these effects persist or worsen, tell your doctor or pharmacist promptly. Methylprednisolone can weaken your immune system, making it easier for you to get an infection. Steroids can also worsen an infection you already have, or reactivate an infection you recently had. Tell your doctor about any illness or infection you have had within the past several weeks. You should also limit caffeine intake colas, tea, coffee and chocolate, especially.
These beverages may irritate your stomach. If you experience symptoms or side effects, especially if severe, be sure to discuss them with your health care team. It is usual to take methylprednisolone once daily at breakfast-time. If you have been told otherwise, you must take the tablets exactly as you have been told by your doctor.
Patients who depend on injectable insulin or other antidiabetic drugs may have to increase their dose while on steroids. It is not uncommon for well-controlled diabetics to see a rise in their blood sugar even on a very short-term dose of steroids. The following table is not intended to be a comprehensive list of side effects. Please consult your pharmacist or physician for a complete list of all side effects.
Methylprednisolone and prednisone are each substrates of the cytochrome P enzyme 3A4. The P enzyme system in the liver is responsible for the metabolism of many drugs, and therefore there is the potential for many drug interactions. Corticosteroids are commonly used in patients who are also on other immunosuppressant agents. One agent may affect the metabolism of another, but they may still be used together if monitored appropriately.
For instance, tacrolimus and cyclosporine are each inhibitors of CYP 3A4. This may lead to increased serum concentrations of methylprednisolone or prednisone when used together.
There have been incidences of convulsions reported with concurrent use of cyclosporine and methylprednisolone, though this is rare. Loop diuretics help manage fluid status in the body by filtering potassium. When given with methylprednisolone or prednisone, however, there is the potential for the body to lose a large amount of potassium.
This could have negative effects on cardiac function. Patients who must take these together should have their electrolyte status monitored closely. The following table is not a list of all possible side effects.
Please consult your healthcare provider for a complete list. Corticosteroids may mask signs of infection and may slow the discovery of new infections. Prolonged use of methylprednisolone and prednisone may lead to cataracts and glaucoma. There have been no well-controlled studies of corticosteroids in pregnant women, therefore their use in pregnancy should only occur when it is clear the benefit outweighs any risks. Infants born to mothers who used corticosteroids during pregnancy should be observed for hypoadrenalism.
Vaccines may not be effective in patients receiving steroids. Live vaccines, such as smallpox, should not be given to patients undergoing corticosteroid therapy. Patients taking immunosuppressive agents are at an increased risk of infection from live vaccines. Methylprednisolone and prednisone may alter the results of skin tests or other allergy testing.
For the most accurate results, steroid therapy should be stopped days prior to administering these tests. Steroids should only be administered for as short a duration as possible to achieve the desired effects.
If long-term use of steroids is medically necessary, they should be kept at the lowest effective dose. Methylprednisolone is a synthetic glucocorticoid used to treat a variety of inflammatory and autoimmune disorders. This medicine may cause changes in mood or behavior for some patients.
Tell your doctor right away if you have depression, mood swings, a false or unusual sense of well-being, trouble with sleeping, or personality changes while using this medicine. This medicine might cause thinning of the bones osteoporosis or slow growth in children if used for a long time.
Tell your doctor if you have any bone pain or if you have an increased risk for osteoporosis. If your child is using this medicine, tell the doctor if you think your child is not growing properly. Make sure any doctor or dentist who treats you knows that you are using this medicine. This medicine may affect the results of certain skin tests.
Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription over-the-counter [OTC] medicines and herbal or vitamin supplements. Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Some side effects may occur that usually do not need medical attention.
These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:. Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.
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Short Half-Life Drugs More concentrated Work faster May need to be dosed multiple times per day to keep blood levels constant. Was this page helpful? Thanks for your feedback! Sign Up.
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